Isolation and Characterization of a Flavonone From the Leaves of Sudanese Geigeria alata(Benth and Hook)- Asteraceae

Abdel Karim, M; Mazen, I; Khalid, M.S

doi:10.53555/bs.v3i7.1637

Abdel Karim, M Sudan University of Science and Technology
Mazen, I Sudan Academy
Khalid, M.S International University

DOI: https://doi.org/10.53555/bs.v3i7.1637

Keywords: : Isolation, Characterization, Flavanone, Geigeria alata, Antibacterial Activity

Abstract

Phytochemical screening of Geigeria alata leaves revealed the presence of flavonoids,tannins
and alkaloids. A flavonoid - compound I- was isolated from ethanol extract by column and thin
layer chromatography and its structure was established on the basis of its spectral data (IR, UV,
NMR and MS). Compound I and different fractions (ethanol, chloroform, n- butanol and ethyl
acetate) of Geigeria alata were screened for their antimicrobial activity against six standard
human pathogens. The ethyl acetate fraction showed excellent antibacterial activity against all
test organisms.However, the ethanol extract was inactive against the test bacteria ,but it gave
good antifungal activity against Aspergillus niger The chloroform and n-butanol fractions
exhibited moderate activity against Escherichia coli .