Quantitative Structure Activity Relationships Studies on Benzimidazole Derivatives as antibacterial agents against Escherichia coli

Abstract

In a continuing effort to develop novel Benzimidazole
endowed with better pharmacological profiles. A series of Benzimidazole
derivatives were designed on the basis of previously developed QSARs.
These drugs offer novel mechanisms of action and expanded spectrums
of activity over traditional treatment option. However, with these new
agents comes the need for increased awareness of the potential
interactions and toxicities associated with these drugs. The best models
for different antibacterial agents against Escherichia coli were first
validated by leave-one-out cross validation procedure. It was revealed
that topological, physicochemical and indicator parameters were found
to have overall significant correlationship with antibacterial activity
against Escherichia coli and these studies provide an insight to design
new molecules.